Phenotypes Associated with This Genotype

Genotype
MGI:5000441

• Allelic Composition: Cd19^tm1Tft/Cd19^tm1Tft
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:66111 )

• following cecal ligation and puncture

immune system

decreased neutrophil cell number ( J:66111 )

• in the peritoneal lavage following cecal ligation and puncture

decreased tumor necrosis factor secretion ( J:66111 )

• in the peritoneal lavage following cecal ligation and puncture

homeostasis/metabolism

increased susceptibility to injury ( J:66111 )

• following cecal ligation and puncture, mice exhibit decreased survival, decreased TNF levels in the peritoneal lavage, decreased neutrophil numbers in the peritoneal lavage, and increased bacteria in the peritoneal lavage compared with wild-type mice

hematopoietic system

decreased neutrophil cell number ( J:66111 )

• in the peritoneal lavage following cecal ligation and puncture