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Phenotypes Associated with This Genotype
Genotype
MGI:5000258
Allelic
Composition
Stx1atm1Tfuj/Stx1atm1Tfuj
Genetic
Background
B6.Cg-Stx1atm1Tfuj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx1atm1Tfuj mutation (2 available); any Stx1a mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• the inhibition ratio is significantly attenuated compared to wild-type controls
• treatment with fluoxetine restores latent inhibition
• when presented with a novel and a familiar object exploring ration for the novel object is significantly lower than in wild-type mice
• increase in the amplitude of the acoustic startle response
• however, the habituation ratio is similar to controls
• over multiple trials investigation time of an initially novel ovariectomized mouse declines much more slowly than in wild-type mice

nervous system
• decrease in glutamate induced serotonin release from hippocampal slices
• in the hypothalamus, hippocampus, and hindbrain
• however, levels of 5-HIAA, a serotonin metabolite, are similar to controls, suggesting impaired serotonin release
• decrease in glutamate induced serotonin release from hypothalamic slices
• however, release in response to maximal stimulation with K+ is similar to wild-type controls

homeostasis/metabolism
• in the hypothalamus, hippocampus, and hindbrain
• however, levels of 5-HIAA, a serotonin metabolite, are similar to controls, suggesting impaired serotonin release

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
disease of mental health DOID:150 J:171786


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory