Mouse Genome Informatics
cx
    Boctm1Rsk/Boctm1Rsk
Cdontm1Rsk/Cdontm1Rsk

B6.129-Boctm1Rsk Cdontm1Rsk
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• display a range of holoprosencephalic phenotypes

craniofacial
N
• do not display cyclopia
• Background Sensitivity: unlike mice on a 129 background, mice on a C57BL/6 background display cleft lip
• proboscis like nose

vision/eye

limbs/digits/tail
N
• do not display digit patterning defects unlike Shh null mice

growth/size/body
• Background Sensitivity: unlike mice on a 129 background, mice on a C57BL/6 background display cleft lip
• proboscis like nose

Mouse Models of Human Disease
OMIM IDRef(s)
Holoprosencephaly 11; HPE11 614226 J:171767