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Phenotypes Associated with This Genotype
Genotype
MGI:5000225
Allelic
Composition		 Bpifa1tm1(KOMP)Vlcg/Bpifa1tm1(KOMP)Vlcg
Genetic
Background		 involves: C57BL/6J * C57BL/6NTac
Cell Lines 10389A-D7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bpifa1tm1(KOMP)Vlcg mutation (0 available); any Bpifa1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:171589 )
• mice infected with Mycoplasma pneumoniae exhibit 3-fold higher M. pneumoniae levels in the lungs, increased lung inflammation, increased neutrophils in the bronchoalveolar lavage fluid, and decreased neutrophil elastase activity compared with wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory