Phenotypes Associated with This Genotype

Genotype
MGI:5000012

• Allelic Composition: Col1a1^{tm11(tetO*-RFP/RNAi:Rpa3)Slowe}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:171348 )

• when treated in utero with doxycycline, mice die shortly after birth

cellular

abnormal cell cycle ( J:171348 )

• doxycycline-treated mouse embryonic fibroblasts arrest in S phase with increased DNA content compared with untreated cells

early cellular replicative senescence ( J:171348 )

• doxycycline-treated mouse embryonic fibroblasts exhibit early cellular replicative senescence compared with untreated cells

• however, withdrawal of doxcycline restores proliferation

normal phenotype

no abnormal phenotype detected ( J:171348 )

• mice treated with doxycycline during adulthood exhibit no abnormal phenotype