Phenotypes Associated with This Genotype

Genotype
MGI:5000006

• Allelic Composition: Col1a1^{tm8(tetO-GFP/RNAi:Rpa3)Slowe}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺; Tg(CMV-rtTA)4Bjd/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:171348 )

• half of mice treated with doxycycline between 5 and 10 weeks of age die prematurely

growth/size/body

weight loss ( J:171348 )

• in doxycycline-treated mice

cellular

abnormal cell cycle ( J:171348 )

• doxycycline-treated mice exhibit cell cycle arrest in the liver, spleen, and intestine unlike control mice