Mouse Genome Informatics
ht
    Guca1atm1.1Hunt/Guca1a+
involves: 129/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• at 5 and 12 months
• the rate of photoreceptor loss declines with age
• at 5 months and progressive with age
• at 5 and 12 months
• at 5 and 12 months
• at 5 and 12 months
• mice exhibit abnormal eye electrophysiology with cone dysfunction that is more severe than rod dysfunction
• mice exhibit impaired rod recovery kinetics from bright flash compared with wild-type mice
• at 3, 5, and 12 months, cone function is reduced with reduced b-wave amplitude compared to in wild-type mice
• 10 Hz and 15 Hz cone flicker electroretinogram is depressed compared to in wild-type mice
• loss of cone response progresses with age
• at 3 months and progressive

nervous system
• at 5 and 12 months
• the rate of photoreceptor loss declines with age
• at 5 months and progressive with age
• at 5 and 12 months
• at 5 and 12 months

Mouse Models of Human Disease
OMIM IDRef(s)
Cone Dystrophy 3; COD3 602093 J:171667