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Phenotypes Associated with This Genotype
Genotype
MGI:4999575
Allelic
Composition		 Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chat/Slc18a3tm1.1Vpra mutation (0 available); any Chat mutation (63 available)
Chat/Slc18a3tm1Vpra mutation (0 available); any Chat mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:171696 )
N
• mice exhibit normal grip force, wire-hanging, gait, and anxiety-related behaviors
hyperactivity ( J:171696 )
• compared with wild-type mice and Chat/Slc18a3tm1Vpra homozygotes

nervous system
abnormal miniature endplate potential ( J:171696 )
• miniature endplate potential amplitude and frequency are increased compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory