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Phenotypes Associated with This Genotype
Genotype
MGI:4950707
Allelic
Composition
Pecam1tm1Mak/Pecam1tm1Mak
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pecam1tm1Mak mutation (1 available); any Pecam1 mutation (223 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• neonatal mutant lungs show a significant reduction in wound-induced endothelial cell (EC) migration relative to wild-type lungs
• however, no significant differences in lung EC content, proliferation or survival are observed
• although appropriately inflated, mutant lungs display a very disorganized architecture at P1
• postnatal mutant lungs display evidence of arrested/delayed alveolarization
• at P7, secondary septation appears to be retarded relative to wild type mice
• by 8 weeks of age (adult), differences in alveolarization are smaller but still present
• at P1, P7 and at 8 weeks (adult), mean alveolar areas are significantly increased while radial alveolar counts are significantly reduced, indicating impaired alveolarization
• however, no significant differences in alveolar cell apoptosis are observed by TUNEL staining
• at P1, mutant primary alveolar sacs are larger than wild-type
• at P1, mutant alveolar walls are thicker than wild-type

cellular
• neonatal mutant lungs show a significant reduction in wound-induced endothelial cell (EC) migration relative to wild-type lungs
• however, no significant differences in lung EC content, proliferation or survival are observed


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory