Mouse Genome Informatics
hm
    Prpf3tm1.1Eap/Prpf3tm1.1Eap
involves: 129S6/SvEvTac * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
N
• no signs of photoreceptor degeneration are detected in mice at up to 24 months of age (J:171561)
• vacuoles are present in the RPE at 24 months of age
• loss of the basal infoldings and accumulation of amorphous deposits between the RPE and Bruch's membrane are seen at 24 months of age
• changes in the RPE are more severe in homozygous mice compared to heterozygous mice
• late onset degeneration of the retinal pigment epithelium
• at 24 months of age, the maximal rod a wave is significantly reduced

pigmentation
• loss of the basal infoldings and accumulation of amorphous deposits between the RPE and Bruch's membrane are seen at 24 months of age
• vacuoles are present in the RPE at 24 months of age
• changes in the RPE are more severe in homozygous mice compared to heterozygous mice

Mouse Models of Human Disease
OMIM IDRef(s)
Retinitis Pigmentosa 18; RP18 601414 J:171561