Phenotypes Associated with This Genotype

Genotype
MGI:4950375

• Allelic Composition: Rhoa^tm1Jrel/Rhoa^tm1Jrel; Tg(Pou3f4-cre)32Cren/0
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:171199 )

• mice die at late embryonic stages

nervous system

nervous system phenotype ( J:171199 )

N • mice exhibit normal basolateral and radial fibers, and glia- and motor neuron generation

increased spinal cord apoptosis ( J:171199 )

• increased apoptosis in the spinal cord at E11.5 and E12.5

premature neuronal precursor differentiation ( J:171199 )

• at E13.5, cultured neurospheres exhibit reduced self-renewal compared with wild-type cells

abnormal neuronal precursor proliferation ( J:171199 )

• at E10.5 and E11.5, spinal cord cells exhibit early cell-cycle exit compared with wild-type cells

abnormal neural tube ventricular layer morphology ( J:171199 )

• at E11.5, spinal cords lack a well-organized ventricular zone and exhibit dysplasia, likely due to neuroepithelial cells invading the lumen of the neural tube, compared with wild-type mice

• rossette-like structures are present in the ventricular zone of the spinal cord unlike in wild-type mice

• at E14.5, the ventricular zone and neural tube lumen are missing unlike in wild-type mice

embryo

abnormal neural tube ventricular layer morphology ( J:171199 )

• at E11.5, spinal cords lack a well-organized ventricular zone and exhibit dysplasia, likely due to neuroepithelial cells invading the lumen of the neural tube, compared with wild-type mice

• rossette-like structures are present in the ventricular zone of the spinal cord unlike in wild-type mice

• at E14.5, the ventricular zone and neural tube lumen are missing unlike in wild-type mice

cellular

increased spinal cord apoptosis ( J:171199 )

• increased apoptosis in the spinal cord at E11.5 and E12.5

premature neuronal precursor differentiation ( J:171199 )

• at E13.5, cultured neurospheres exhibit reduced self-renewal compared with wild-type cells

abnormal neuronal precursor proliferation ( J:171199 )

• at E10.5 and E11.5, spinal cord cells exhibit early cell-cycle exit compared with wild-type cells