Mouse Genome Informatics
ot
    Fmr1tm1Usdn/Y
involves: 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• in the open field, the number of center entries were higher in mutants than wild-type mice at all times points, consistent with hyperactivity and lower anxiety (J:170720)
• fraction of distance moved in the margins of the field is consistently lower in mutants than wild-type, indicating lower anxiety (J:170720)
• although times spent in the open and closed arms of the elevated plus maze were similar for mutants and wild-type mice, mutants make 34% more entries into the open arms than wild-type mice (J:170720)
• in the elevated zero maze, mutants on average spend 81% more time in the open quadrants than wild-type, indicating lower general anxiety (J:170720)
• in the passive avoidance test, the average latency of mutants to enter the dark compartment after a one-trial training session is 32% of the latency of wild-type mice (J:170720)
• mutants exhibit a higher total horizontal distance moved in the open field and a higher number of open entries in the elevated plus maze, indicating hyperactivity (J:170720)
• average numbers of entries into both chambers in the social novelty test is higher for mutants, again, indicating hyperactivity (J:170720)
• overall, mutants exhibit similar behavior as wild-type mice on the social interaction test, however mutants spend less time in the two side chambers and an increased amount of time in the center during social novelty compared with wild-type mice suggesting some social anxiety (J:170720)

endocrine/exocrine glands
• average testis weight is 15% higher than in wild-type (J:170720)

nervous system
• rates of cerebral protein synthesis are consistently higher in mutants than in wild-type mice by about 10-21% (J:170720)
• arborization is reduced in both apical and basal dendrites of layer III pyramidal neurons in medial prefrontal cortex (J:170720)
• overall arborization of apical dendrites of CA3 pyramidal cells of the dorsal hippocampus is reduced in mutants, but the shapes of the curves are similar; branching is reduced in the area between 100 and 175 um from the soma, but appears normal between 25 and 75 um and at 200 um from the soma (J:170720)
• branching on dendrites of pyramidal-like cells in the basal lateral amygdala is lower in mutants between 50 and 17 um form the soma (J:170720)
• branching on dendrites of stellate cells in the basal lateral amygdala is lower in mutants between 75 and 150 um from the soma (J:170720)
• in medial prefrontal cortex, spine densities are higher in mutants by 35 and 25% on apical and basal dendrites, respectively (J:170720)
• in CA3 pyramidal cells, spine densities are increased by 8 and 26% on apical and basal dendrites, respectively (J:170720)
• in basal lateral amygdala pyramidal-like cells, spine densities are increased by 48 and 41% on apical and basal dendrites, respectively (J:170720)
• in basal lateral amygdala stellate cells, spine densities are 18 and 25% higher on apical and basal dendrites, respectively (J:170720)
• in the medial prefrontal cortex, CA3 pyramidal cells and in the basal lateral amygdala, spines on both apical and basal dendrites are longer in mutants than in wild-type mice (J:170720)

reproductive system
• average testis weight is 15% higher than in wild-type (J:170720)

Mouse Models of Human Disease
OMIM IDRef(s)
Fragile X Mental Retardation Syndrome 300624 J:170720