Mouse Genome Informatics
cn
    Mettm1Sst/Mettm1Sst
Tg(mI56i-cre,EGFP)1Kc/0

involves: 129P2/OlaHsd * C57BL/6J * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
N
• in the Morris water maze, mutants have a longer latency to locate the platform on the first 2 days of training than controls, however performance on the probe test and reversal probe test were normal, indicating normal hippocampal-mediated spatial learning (J:170554)
• open field activity and anxiety are not affected (J:170554)
• on reversal discriminations, mutants require more trials than controls, indicating impaired reversal learning
• mutants show increased latency performance on the cued-platform test, indicating a delay in striatal-dependent cued learning

nervous system
• marker analysis indicates an increase in numbers of PV+ and SST+ striatal GABAergic interneurons
• distribution of striatal interneurons is altered, with fewer cells of the population located in the medial (associative) regions and more cells in the lateral (sensorimotor) areas
• reduction in the numbers of PV+ GABAergic interneurons in the primary somatosensory cortex (28% loss) and the orbitofrontal cortex (31% loss)
• marker analysis indicates an increase in numbers of PV+ and SST+ striatal GABAergic interneurons
• however, striatum appears normal
• 31% reduction in PV+ cells in the orbitofrontal cortex
• 28% loss of PV+ cells in primary somatosensory cortex

Mouse Models of Human Disease
OMIM IDRef(s)
Autism, Susceptibility to, 9; AUTS9 611015 J:170554
Gilles De La Tourette Syndrome; GTS 137580 J:170554