Phenotypes Associated with This Genotype

Genotype
MGI:4950068

• Allelic Composition: Met^tm1Sst/Met^tm1Sst; Tg(mI56i-cre,EGFP)1Kc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:170554 )

N • in the Morris water maze, mutants have a longer latency to locate the platform on the first 2 days of training than controls, however performance on the probe test and reversal probe test were normal, indicating normal hippocampal-mediated spatial learning

N • open field activity and anxiety are not affected

abnormal learning/memory/conditioning ( J:170554 )

• on reversal discriminations, mutants require more trials than controls, indicating impaired reversal learning

impaired cued conditioning behavior ( J:170554 )

• mutants show increased latency performance on the cued-platform test, indicating a delay in striatal-dependent cued learning

nervous system

abnormal brain interneuron morphology ( J:170554 )

• marker analysis indicates an increase in numbers of PV+ and SST+ striatal GABAergic interneurons

• distribution of striatal interneurons is altered, with fewer cells of the population located in the medial (associative) regions and more cells in the lateral (sensorimotor) areas

• reduction in the numbers of PV+ GABAergic interneurons in the primary somatosensory cortex (28% loss) and the orbitofrontal cortex (31% loss)

abnormal striatum morphology ( J:170554 )

• marker analysis indicates an increase in numbers of PV+ and SST+ striatal GABAergic interneurons

• however, striatum appears normal

abnormal orbitofrontal cortex morphology ( J:170554 )

• 31% reduction in PV+ cells in the orbitofrontal cortex

abnormal primary somatosensory cortex morphology ( J:170554 )

• 28% loss of PV+ cells in primary somatosensory cortex

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:170554
Gilles de la Tourette syndrome		DOID:11119	OMIM:137580	J:170554