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Phenotypes Associated with This Genotype
Genotype
MGI:4950056
Allelic
Composition
Pld4thss/Pld4thss
Genetic
Background
BALB/cJ-Pld4thss/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld4thss mutation (1 available); any Pld4 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Smaller body size of the Pld4thss/Pld4thss mouse (upper left) cmpared to a heterozygote (lower right) at 20 days of age

hematopoietic system
• significant splenomegaly at 15 weeks of age with 1.5 to 2-fold more splenocytes than in heterozygotes, and the degree of splenomegaly is inversely proportional to body weight
• approximately 1.5 to 2-fold more splenocytes in homozygotes than heterozygotes
• increased CD69+ T cells indicative of an activation
• females, not males, were assessed and found to have remarkable spontaneous formation of germinal centres in the spleen and lymphoid organs
• hypergammaglobulinemia at 14 to 15 weeks of age inlcuding significant increases in IgM, IgG2b, IgG3, IgA, and IgE

mortality/aging
N
• normal lifespan

renal/urinary system
• PAS-positive depositions and IgG and C3 deposits are found in the glomeruli of homozygotes but not heterozygotes although urine protein adjusted for cratinine is not significantly elevated

integument
• the coat grows in sparsely and a sparse coat persists throughout the lifespan, which is normal

growth/size/body
• smaller than normal body size is evident before the hair begins to grow in
• evident by 1 week of age and worsens with age
• significant splenomegaly at 15 weeks of age with 1.5 to 2-fold more splenocytes than in heterozygotes, and the degree of splenomegaly is inversely proportional to body weight
• approximately 1.5 to 2-fold more splenocytes in homozygotes than heterozygotes

immune system
• significant splenomegaly at 15 weeks of age with 1.5 to 2-fold more splenocytes than in heterozygotes, and the degree of splenomegaly is inversely proportional to body weight
• approximately 1.5 to 2-fold more splenocytes in homozygotes than heterozygotes
• increased CD69+ T cells indicative of an activation
• females, not males, were assessed and found to have remarkable spontaneous formation of germinal centres in the spleen and lymphoid organs
• hypergammaglobulinemia at 14 to 15 weeks of age inlcuding significant increases in IgM, IgG2b, IgG3, IgA, and IgE
• significant lymphadenopathy at 15 weeks of age compared with heterozygotes, and the degree of lymphadenopathy is inversly proportional to body weight


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory