Phenotypes Associated with This Genotype

Genotype
MGI:4950023

• Allelic Composition: Chrna7^tm1Bay/Chrna7^tm1Bay
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal airway basal cell differentiation ( J:154705 )

• after polidocanol-induced acute injury, 8-wk old mutant mice display delayed regeneration of the tracheal epithelium with a transient hyperplasia of basal cells observed on days 4 and 6, but not on day 8, after injury

airway basal cell hyperplasia ( J:154705 )

• at 1 year of age, the % of 1-2 layers of basal cells in the tracheal epithelium is reduced whereas the % of 3-4 layers of basal cells in increased by 3.8-fold relative to that in wild-type controls

cellular

abnormal airway basal cell differentiation ( J:154705 )

• after polidocanol-induced acute injury, 8-wk old mutant mice display delayed regeneration of the tracheal epithelium with a transient hyperplasia of basal cells observed on days 4 and 6, but not on day 8, after injury

immune system

immune system phenotype ( J:103908 )

N • IgM levels of preimmune serum are little altered from control levels

decreased immunoglobulin level ( J:103908 )

• significantly reduced preimmune serum Ig levels

decreased IgG level ( J:103908 )

hematopoietic system

decreased immunoglobulin level ( J:103908 )

• significantly reduced preimmune serum Ig levels

decreased IgG level ( J:103908 )