Mouse Genome Informatics
ot
    Mecp2tm1Vnar/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype

Frontal cortex and olfactory bulbs of Mecp2tm1Vnar/Y mice exhibit an increase in cell density

mortality/aging
N
• mice live longer than 14 months with no unusual health issues

reproductive system
• mice do not successfully reproduce

nervous system
• cell density in the CA1, CA2, and CA3 of the hippocampus is increased compared to in wild-type mice
• cell density in the dentate gyrus is increased compared to in wild-type mice
• cell density in the frontal cortex is increased compared to in wild-type mice
• cell density in the olfactory bulb is increased compared to in wild-type mice
• cell density in the cerebellum is increased compared to in wild-type mice
• cell density in the granule cell layer of the cerebellum is increased compared to in wild-type mice
• cortical neurons exhibit abnormal dendritic branching and decreased dendritic complexity compared with wild-type neurons

behavior/neurological
N
• mice do not exhibit seizures or tremors

growth/size/body
N
• mice exhibit normal weight gain

Mouse Models of Human Disease
OMIM IDRef(s)
Rett Syndrome; RTT 312750 J:171410