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Phenotypes Associated with This Genotype
Genotype
MGI:4949888
Allelic
Composition
Mecp2tm1Vnar/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Vnar mutation (0 available); any Mecp2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Frontal cortex and olfactory bulbs of Mecp2tm1Vnar/Y mice exhibit an increase in cell density

mortality/aging
N
• mice live longer than 14 months with no unusual health issues

reproductive system
• mice do not successfully reproduce

nervous system
• cell density in the CA1, CA2, and CA3 of the hippocampus is increased compared to in wild-type mice
• cell density in the dentate gyrus is increased compared to in wild-type mice
• cell density in the frontal cortex is increased compared to in wild-type mice
• cell density in the olfactory bulb is increased compared to in wild-type mice
• cell density in the cerebellum is increased compared to in wild-type mice
• cell density in the granule cell layer of the cerebellum is increased compared to in wild-type mice
• cortical neurons exhibit abnormal dendritic branching and decreased dendritic complexity compared with wild-type neurons

behavior/neurological
N
• mice do not exhibit seizures or tremors

growth/size/body
N
• mice exhibit normal weight gain

Mouse Models of Human Disease
OMIM ID Ref(s)
Rett Syndrome; RTT 312750 J:171410


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory