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Phenotypes Associated with This Genotype
Genotype
MGI:4949537
Allelic
Composition
Agpsbs2/Agpsbs2
Genetic
Background
STOCK Agpsbs2/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agpsbs2 mutation (1 available); any Agps mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some prenatal or perinatal lethality (J:171265)
• some prenatal or perinatal lethality (J:171265)

reproductive system
• mice exhibit abnormal seminiferous tubules with multinucleate cells within the lumen compared with wild-type mice (J:171265)
• mice exhibit abnormal seminiferous tubules with multinucleate cells within the lumen compared with wild-type mice (J:171265)
(J:171265)
(J:171265)
• mature spermatozoa or elongating spermatids are absent unlike in wild-type mice (J:171265)
• mature spermatozoa or elongating spermatids are absent unlike in wild-type mice (J:171265)
(J:156373)
(J:156373)
(J:171265)
(J:171265)

vision/eye
• mice exhibit bladder cells and liquefied lens material within the cortex and morganian globules at the posterior poles unlike in wild-type mice (J:171265)
• mice exhibit bladder cells and liquefied lens material within the cortex and morganian globules at the posterior poles unlike in wild-type mice (J:171265)
• fiber cells in the bow region are smaller in size mice and detached from the epithelium compared to in wild-type mice (J:171265)
• fiber cells in the bow region are smaller in size mice and detached from the epithelium compared to in wild-type mice (J:171265)

homeostasis/metabolism
• mice exhibit reduced brain phosphatidylethanolamine (PE), ether-phosphatidyl ethanolamine (ePE), and ether-phosphatidyl choline (ePC) levels compared with wild-type mice (J:171265)
• however, levels of phosphatidylcholine (PC) are normal (J:171265)
• mice exhibit reduced brain phosphatidylethanolamine (PE), ether-phosphatidyl ethanolamine (ePE), and ether-phosphatidyl choline (ePC) levels compared with wild-type mice (J:171265)
• however, levels of phosphatidylcholine (PC) are normal (J:171265)

endocrine/exocrine glands
• mice exhibit abnormal seminiferous tubules with multinucleate cells within the lumen compared with wild-type mice (J:171265)
• mice exhibit abnormal seminiferous tubules with multinucleate cells within the lumen compared with wild-type mice (J:171265)
(J:171265)
(J:171265)

Mouse Models of Human Disease
OMIM ID Ref(s)
Rhizomelic Chondrodysplasia Punctata, Type 3; RCDP3 600121 J:171265


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory