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Phenotypes Associated with This Genotype
Genotype
MGI:4949262
Allelic
Composition		 Lefty1tm1Hmd/Lefty1tm1Hmd
Tg(Hhex-EGFP)#Rbe/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lefty1tm1Hmd mutation (1 available); any Lefty1 mutation (41 available)
Tg(Hhex-EGFP)#Rbe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal anterior visceral endoderm cell migration ( J:170681 )
• 5 of 7 mice exhibit an anterior visceral endoderm (AVE) migration defect (1 arrested migration; 4 over-migration) compared with wild-type mice
• 5 of 13 mice exhibit mild AVE migration defects (1 slight delay; 4 slight over-migration) compared with wild-type mice

cellular
abnormal anterior visceral endoderm cell migration ( J:170681 )
• 5 of 7 mice exhibit an anterior visceral endoderm (AVE) migration defect (1 arrested migration; 4 over-migration) compared with wild-type mice
• 5 of 13 mice exhibit mild AVE migration defects (1 slight delay; 4 slight over-migration) compared with wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory