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Phenotypes Associated with This Genotype
Genotype
MGI:4949135
Allelic
Composition		 Hcrtr2tm1Tesc/Hcrtr2tm1Tesc
Genetic
Background		 B6.129-Hcrtr2tm1Tesc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcrtr2tm1Tesc mutation (1 available); any Hcrtr2 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:170824 )
N
• following bilateral microinjection of AAV-Cre into the tuberomammillary nucleus region maintenance of wakefulness is markedly improved compared to non-Cre treated
fragmentation of sleep/wake states ( J:170824 )
• bilateral microinjection of AAV-Cre dorsal into the posterior thalamus region fails to improve wakefulness
• mice with bilateral microinjection of AAV-Cre into the tuberomammillary nucleus region still have fragmented sleep with shorter non-REM bouts

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory