Phenotypes Associated with This Genotype

Genotype
MGI:4948937

• Allelic Composition: Egln1^tm1.1Brei/Egln1^tm1.1Brei; Myl2^tm1(cre)Krc/Myl2⁺
• Genetic Background: B6.Cg-Myl2^tm1(cre)Krc Egln1^tm1.1Brei

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:170943 )

N • mice exhibit normal cardiac response to increased afterload

abnormal coronary vessel morphology ( J:170943 )

• capillary area is increased compared to in wild-type hearts

• however, capillary number is normal

abnormal response to cardiac infarction ( J:170943 )

• following ligation of the left anterior descending artery, mice exhibit decreased area at risk, area of necrosis, apoptosis, and reduced decrease in fractional shortening compared with similarly treated wild-type mice

decreased myocardial infarct size ( J:170943 )

• following ligation of the left anterior descending artery, mice exhibit decreased area at risk and area of necrosis compared with similarly treated wild-type mice

homeostasis/metabolism

abnormal response to cardiac infarction ( J:170943 )

• following ligation of the left anterior descending artery, mice exhibit decreased area at risk, area of necrosis, apoptosis, and reduced decrease in fractional shortening compared with similarly treated wild-type mice

decreased myocardial infarct size ( J:170943 )

• following ligation of the left anterior descending artery, mice exhibit decreased area at risk and area of necrosis compared with similarly treated wild-type mice

muscle

decreased cardiomyocyte apoptosis ( J:170943 )

• following ligation of the left anterior descending artery

cellular

decreased cardiomyocyte apoptosis ( J:170943 )

• following ligation of the left anterior descending artery