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Phenotypes Associated with This Genotype
Genotype
MGI:4948355
Allelic
Composition		 Pkd2lrm4/Pkd2lrm4
Genetic
Background		 C3.CAnN-Pkd2lrm4
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd2lrm4 mutation (2 available); any Pkd2 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:170490 )
• embryos fail to survive significantly beyond E14.5

embryo
embryo phenotype ( J:170490 )
N
• embryonic node cilia motion appears normal
abnormal direction of embryo turning ( J:170490 )
• at E9.5 embryos display normal or inverted turning
abnormal left-right axis patterning ( J:170490 )
• expression analysis detects defect in left-right asymmetry of the lateral plate mesoderm

homeostasis/metabolism
edema ( J:170490 )
• in 31 of 33 embryos

growth/size/body
right-sided stomach ( J:170490 )
• in some embryos
right pulmonary isomerism ( J:170490 )
• in 37 of 38 embryos

cardiovascular system
dextrocardia ( J:170490 )
• in some embryos

digestive/alimentary system
right-sided stomach ( J:170490 )
• in some embryos

respiratory system
right pulmonary isomerism ( J:170490 )
• in 37 of 38 embryos

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory