Phenotypes Associated with This Genotype

Genotype
MGI:4948352

• Allelic Composition: Pkd1l1^rks/Pkd1l1^rks
• Genetic Background: C3H.B6-Pkd1l1^rks

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:170490 )

• most embryos die by E15.5 and the few remaining embryos are developmentally delayed and close to death

embryo

embryo phenotype ( J:170490 )

N • embryonic node cilia motion appears normal

abnormal direction of embryo turning ( J:170490 )

• at E9.5 embryos display normal, inverted or indifferent turning

abnormal left-right axis patterning ( J:170490 )

• expression analysis detects defect in left-right asymmetry of the lateral plate mesoderm

embryonic growth arrest ( J:170490 )

• arrest around E14.5

embryonic growth retardation ( J:170490 )

• the few embryos alive at E15.5 are developmentally delayed

homeostasis/metabolism

edema ( J:170490 )

• in 25 of 28 embryos at E13.5 - E14.5

growth/size/body

right-sided stomach ( J:170490 )

• in some embryos at E13.5 - E14.5

embryonic growth retardation ( J:170490 )

• the few embryos alive at E15.5 are developmentally delayed

right pulmonary isomerism ( J:170490 )

• seen in all embryos

cardiovascular system

dextrocardia ( J:170490 )

• in some embryos at E13.5 - E14.5

digestive/alimentary system

right-sided stomach ( J:170490 )

• in some embryos at E13.5 - E14.5

respiratory system

right pulmonary isomerism ( J:170490 )

• seen in all embryos