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Phenotypes Associated with This Genotype
Genotype
MGI:4948269
Allelic
Composition
Cdc14btm1.2Pzg/Cdc14btm1.2Pzg
Genetic
Background
B6.129P2-Cdc14btm1.2Pzg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc14btm1.2Pzg mutation (1 available); any Cdc14b mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• including premature cataracts and kyphosis

reproductive system
• particularly from female mice
• particularly from female mice

vision/eye
• mice exhibit loose and thickened cornea compared with wild-type mice
• mice exhibit invaginations in the ocular lens compared with wild-type mice
• premature

cellular
N
• mouse embryonic fibroblasts exhibit normal DNA damage checkpoints
• in mouse embryonic fibroblasts
• mouse embryonic fibroblasts exhibit defective DNA damage repair compared with wild-type cells

behavior/neurological
N
• mice exhibit normal cued conditioning

skeleton
• premature

homeostasis/metabolism
• mouse embryonic fibroblasts exhibit defective DNA damage repair compared with wild-type cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory