nervous system
• increase in the number of Schwann cells around the quadriceps femoral nerves at 13 months of age is less than that in age matched mutant mice heterozygous for the Rag1 null allele
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• pathological lesions indicative of compromised myelin maintenance in the quadriceps femoral nerves at 13 months of age are less severe than those in age matched mutant mice heterozygous for the Rag1 null allele
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• myelin sheaths of quadriceps femoral nerves at 13 months of age are thicker than those in age matched mutant mice heterozygous for the Rag1 null allele
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• myelin degeneration in the quadriceps femoral nerves at 13 months of age is less severe than in age matched mutant mice heterozygous for the Rag1 null allele
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• impaired conduction with prolonged latencies of M-responses and of F waves after distal or proximal stimulations
• impairment is less severe than in mutant mice heterozygous for the Rag1 null allele
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immune system
hematopoietic system
cellular
• increase in the number of Schwann cells around the quadriceps femoral nerves at 13 months of age is less than that in age matched mutant mice heterozygous for the Rag1 null allele
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