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Phenotypes Associated with This Genotype
Genotype
MGI:4947955
Allelic
Composition
Mpztm1Msch/Mpz+
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
B6.129S7-Mpztm1Msch Rag1tm1Mom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpztm1Msch mutation (0 available); any Mpz mutation (28 available)
Rag1tm1Mom mutation (56 available); any Rag1 mutation (132 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increase in the number of Schwann cells around the quadriceps femoral nerves at 13 months of age is less than that in age matched mutant mice heterozygous for the Rag1 null allele
• pathological lesions indicative of compromised myelin maintenance in the quadriceps femoral nerves at 13 months of age are less severe than those in age matched mutant mice heterozygous for the Rag1 null allele
• myelin sheaths of quadriceps femoral nerves at 13 months of age are thicker than those in age matched mutant mice heterozygous for the Rag1 null allele
• myelin degeneration in the quadriceps femoral nerves at 13 months of age is less severe than in age matched mutant mice heterozygous for the Rag1 null allele
• impaired conduction with prolonged latencies of M-responses and of F waves after distal or proximal stimulations
• impairment is less severe than in mutant mice heterozygous for the Rag1 null allele

immune system

hematopoietic system

cellular
• increase in the number of Schwann cells around the quadriceps femoral nerves at 13 months of age is less than that in age matched mutant mice heterozygous for the Rag1 null allele


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory