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Phenotypes Associated with This Genotype
Genotype
MGI:4947712
Allelic
Composition
Lama2tm1Eeng/Lama2tm1Eeng
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama2tm1Eeng mutation (1 available); any Lama2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some newborn death is observed (J:170192)
• some newborn death is observed (J:170192)

muscle
• inflammation is seen in muscles, with macrophage infiltration in foci of TN-C expression in mutant muscle and induction of TNFalpha and IL-1beta (J:170192)
• inflammation is seen in muscles, with macrophage infiltration in foci of TN-C expression in mutant muscle and induction of TNFalpha and IL-1beta (J:170192)
• necrotic muscle cell death (J:170192)
• necrotic muscle cell death (J:170192)
• hindlimb weakness is evident by 2 to 3 weeks of age (J:170192)
• inward contraction and slight tremors of hindlimbs are seen when mutants are suspended (J:170192)
• hindlimb fatigue and dragging are seen at later stages (J:170192)
• hindlimb weakness is evident by 2 to 3 weeks of age (J:170192)
• inward contraction and slight tremors of hindlimbs are seen when mutants are suspended (J:170192)
• hindlimb fatigue and dragging are seen at later stages (J:170192)

growth/size/body
• small size is seen by 7 days of age (J:170192)
• small size is seen by 7 days of age (J:170192)

behavior/neurological
• hindlimb paralysis and rigid contractures occur in mutants surviving past 8 weeks of age (J:170192)
• hindlimb paralysis and rigid contractures occur in mutants surviving past 8 weeks of age (J:170192)

immune system
• inflammation is seen in muscles, with macrophage infiltration in foci of TN-C expression in mutant muscle and induction of TNFalpha and IL-1beta (J:170192)
• inflammation is seen in muscles, with macrophage infiltration in foci of TN-C expression in mutant muscle and induction of TNFalpha and IL-1beta (J:170192)

Mouse Models of Human Disease
OMIM ID Ref(s)
Muscular Dystrophy, Congenital Merosin-Deficient, 1A; MDC1A 607855 J:170192


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory