Mouse Genome Informatics
hm
    Lama2tm1Eeng/Lama2tm1Eeng
involves: 129S1/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• some newborn death is observed

muscle
• inflammation is seen in muscles, with macrophage infiltration in foci of TN-C expression in mutant muscle and induction of TNFalpha and IL-1beta
• necrotic muscle cell death
• hindlimb weakness is evident by 2 to 3 weeks of age
• inward contraction and slight tremors of hindlimbs are seen when mutants are suspended
• hindlimb fatigue and dragging are seen at later stages

growth/size/body
• small size is seen by 7 days of age

behavior/neurological
• hindlimb paralysis and rigid contractures occur in mutants surviving past 8 weeks of age

immune system
• inflammation is seen in muscles, with macrophage infiltration in foci of TN-C expression in mutant muscle and induction of TNFalpha and IL-1beta

Mouse Models of Human Disease
OMIM IDRef(s)
Muscular Dystrophy, Congenital Merosin-Deficient, 1A; MDC1A 607855 J:170192