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Phenotypes Associated with This Genotype
Genotype
MGI:4947236
Allelic
Composition		 Lrattm1Kpal/Lrattm1Kpal
Rhotm1.1Kpal/Rho+
Rpe65450L/Rpe65450M
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrattm1Kpal mutation (1 available); any Lrat mutation (26 available)
Rhotm1.1Kpal mutation (1 available); any Rho mutation (48 available)
Rpe65450L mutation (1 available); any Rpe65 mutation (48 available)
Rpe65450M mutation (0 available); any Rpe65 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Effect of genetic depletion of 11-cis-retinal production (Lrattm1Kpal/Lrattm1Kpal) on retinal degeneration in Rhotm1.1Kpal/Rho+ mice

vision/eye
decreased retina photoreceptor cell number ( J:170648 )
• dramatically reduced at P36
abnormal retina rod cell outer segment morphology ( J:170648 )
• less than in Rhotm1.1Kpal heterozygotes
retina photoreceptor degeneration ( J:170648 )
• due to increased apoptosis
retina rod cell degeneration ( J:170648 )
• less than in Rhotm1.1Kpal heterozygotes

nervous system
decreased retina photoreceptor cell number ( J:170648 )
• dramatically reduced at P36
abnormal retina rod cell outer segment morphology ( J:170648 )
• less than in Rhotm1.1Kpal heterozygotes
retina photoreceptor degeneration ( J:170648 )
• due to increased apoptosis
retina rod cell degeneration ( J:170648 )
• less than in Rhotm1.1Kpal heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory