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Phenotypes Associated with This Genotype
Genotype
MGI:4946639
Allelic
Composition
Tdrd5tm1Sait/Tdrd5tm1Sait
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tdrd5tm1Sait mutation (0 available); any Tdrd5 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Sterility in Tdrd5tm1Sait/Tdrd5tm1Sait males

reproductive system
N
• female mice are fertile
• fewer round spermatids are observed compared to in wild-type mice
• pachytene spermatocytes exhibit underdevelopped inter-mitochondrial cements and chromatoid bodies compared with wild-type mice
• at stages XII and I-III seminiferous tubules
• as early as 4 weeks of age
• as early as 4 weeks of age
• no elongating spermatids are present in the seminiferous tubules unlike in wild-type mice
• mice exhibit occasional failure of meiotic prophase unlike in wild-type mice
• male mice are infertile
• however, round spermatids are capable of producing fertile offspring when injected into oocytes

cellular
• fewer round spermatids are observed compared to in wild-type mice
• pachytene spermatocytes exhibit underdevelopped inter-mitochondrial cements and chromatoid bodies compared with wild-type mice
• expression of LINE retrotransposons is derepressed in male germ cells unlike in wild-type cells
• at stages XII and I-III seminiferous tubules

endocrine/exocrine glands
• as early as 4 weeks of age
• as early as 4 weeks of age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory