Phenotypes Associated with This Genotype

Genotype
MGI:4946506

• Allelic Composition: Mtf2^tm1.1Hko/Mtf2^tm1.1Hko; Pcgf2^tm1Hko/Pcgf2^tm1Hko
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:170279 )

• no mice are observed at the perinatal stage

skeleton

abnormal occipital bone morphology ( J:170279 )

• segmented, forming an ectopic arch

abnormal supraoccipital bone morphology ( J:170279 )

• 90% of mice exhibit supraoccipital bone to C1 transformation

scapular bone foramen ( J:170279 )

increased rib number ( J:170279 )

• C7 forms perfect ribs

vertebral transformation ( J:170279 )

• at E16.5, homeotic transformations are more stringent than in single homozygotes

thoracic vertebral transformation ( J:170279 )

• 70% of mice exhibit T8 to T9 transformation

• 90% of mice exhibit T13 to L1 transformation

cervical vertebral transformation ( J:170279 )

• C1 is identical to C2 unlike in wild-type mice

• C7 forms perfect ribs

• 70% of mice exhibit C2 to C3 transformation

lumbar vertebral transformation ( J:170279 )

• 100% of mice exhibit L6 to S1 transforamtion

craniofacial

abnormal occipital bone morphology ( J:170279 )

• segmented, forming an ectopic arch

abnormal supraoccipital bone morphology ( J:170279 )

• 90% of mice exhibit supraoccipital bone to C1 transformation