Phenotypes Associated with This Genotype

Genotype
MGI:4946505

• Allelic Composition: Mtf2^tm1.1Hko/Mtf2^tm1.1Hko; Suz12^tm1Hko/Suz12⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal sternum morphology ( J:170279 )

• shifted anteriorly

increased rib number ( J:170279 )

• perfect ribs are associated with C7

vertebral transformation ( J:170279 )

• homeotic transformation is enhanced compared to in Mtf2^tm1.1Hko homozygotes

thoracic vertebral transformation ( J:170279 )

• unlike in wild-type mice, a prominent spinous process is associated with T1 instead of T2

• 75% of mice exhibit T1 to T2 transformation

• 75% of mice exhibit T13 to L1 transformation

cervical vertebral transformation ( J:170279 )

• unlike in wild-type mice, anterior tuberculums are associated with C5 instead of C6 and perfect ribs are associated with C7

• 25% of mice exhibit C1 to C2 transforamtion

• 42% of mice exhibit C2 to C3 transformation

• 42% of mice exhibit C5 to C6 transformation

• 58% of mice exhibit C6 to T1 transformation

lumbar vertebral transformation ( J:170279 )

• 92% of mice exhibit L6 to S1 transformation