Phenotypes Associated with This Genotype

Genotype
MGI:4946407

• Allelic Composition: Npy1r^tm1Wpg/Npy1r^tm1Wpg; Tg(Col1a1-cre)2Bek/0
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoblast physiology ( J:170291 )

• mice exhibit increased osteoblast activity compared to in wild-type mice

increased diameter of femur ( J:170291 )

• with an increase in total tissue area, marrow area, periosteal perimeter and endosteal perimeter

increased bone mineral content ( J:170291 )

• whole body and lumbar vertebrae

increased bone mineral density ( J:170291 )

increased bone trabecula number ( J:170291 )

increased trabecular bone thickness ( J:170291 )

abnormal bone ossification ( J:170291 )

• bone formation rate in cancellous and cortical bone is increased compared to in wild-type mice

increased bone strength ( J:170291 )

limbs/digits/tail

increased diameter of femur ( J:170291 )

• with an increase in total tissue area, marrow area, periosteal perimeter and endosteal perimeter

cellular

abnormal osteoblast physiology ( J:170291 )

• mice exhibit increased osteoblast activity compared to in wild-type mice