Phenotypes Associated with This Genotype

Genotype
MGI:4946095

• Allelic Composition: Myh10^tm7Rsad/Myh10^tm7Rsad; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal intercalated disk morphology ( J:170148 )

• widened and distorted in 4 of 5 mice

increased myocardial fiber size ( J:170148 )

• at P0, 6 months, and 10 months with abnormal nuclei

ventricular septal defect ( J:170148 )

• in 2 of 9 mice without double outlet heart right ventricle

cardiac interstitial fibrosis ( J:170148 )

• at 10 months

decreased cardiac muscle contractility ( J:170148 )

• at 10 months

abnormal impulse conducting system conduction ( J:170148 )

cardiomyopathy ( J:170148 )

• at 10 months, mice exhibit increased left ventricular internal diameter at the end of systole and decreased fractional shortening with abnormal intercalated disc compared with wild-type mice

heart inflammation ( J:170148 )

• at 6 and 10 months

homeostasis/metabolism

abnormal atrial thrombosis ( J:170148 )

• in the atrium of 2 in 8 mice at 10 months

immune system

heart inflammation ( J:170148 )

• at 6 and 10 months

muscle

abnormal intercalated disk morphology ( J:170148 )

• widened and distorted in 4 of 5 mice

increased myocardial fiber size ( J:170148 )

• at P0, 6 months, and 10 months with abnormal nuclei

decreased cardiac muscle contractility ( J:170148 )

• at 10 months

cardiomyopathy ( J:170148 )

• at 10 months, mice exhibit increased left ventricular internal diameter at the end of systole and decreased fractional shortening with abnormal intercalated disc compared with wild-type mice

increased cardiomyocyte apoptosis ( J:170148 )

cellular

cardiac interstitial fibrosis ( J:170148 )

• at 10 months

increased cardiomyocyte apoptosis ( J:170148 )