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Phenotypes Associated with This Genotype
Genotype
MGI:4946082
Allelic
Composition
Lrp5tm1Dgen/Lrp5tm1Dgen
Genetic
Background
B6.129P2-Lrp5tm1Dgen/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1Dgen mutation (1 available); any Lrp5 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mutants do not exhibit the postnatal decrease in hyaloid vessels observed in controls at P10 (J:169924)
• mice have about double the number of hyaloid vessels branching from the hyaloid artery indicating persistent hyaloid vessels (J:235600)
• treatment with lithium from P1 to P7 reduces the number of hyaloid vessels in P8 eyes by about 30% (J:235600)
• decrease in outer retina thickness
• mice show secondary inner-retinal hypoxia
• mice show less retinal vascular coverage and fewer branching points in the central superficial vascular plexus at P7, indicating delayed development of retinal vasculature
• daily treatment with lithium from P1 to P7 accelerates retinal vascular growth, results in a 7.6% increase in superficial plexus vascular coverage and 42% increase in the number of branching points at P7
• mice show defective vascular migration into the inner retina at P17
• mice develop vascular growth in the superficial plexus with glomeruloid vascular structures at P17
• lithium treatment from P1 to P16 reduces the retinal area of glomeruloid vessels by about 60%
• lithium treatment from P1 to P16 normalizes the appearance of finely pruned vessels and the abnormally increased vascular density in the superficial vascular layer
• mice show a complete absence of intralaminar (intermediate and deep layers of) retinal vessels at P17
• eyes show decreased thickness of the whole retina
• lithium treatment partially restores both the whole retinal and inner retinal thickness
• b-wave responses are attenuated in P30 mice
• treatment with lithium restores b-wave sensitivity
• decrease in visual function

cardiovascular system
• mice show less retinal vascular coverage and fewer branching points in the central superficial vascular plexus at P7, indicating delayed development of retinal vasculature
• daily treatment with lithium from P1 to P7 accelerates retinal vascular growth, results in a 7.6% increase in superficial plexus vascular coverage and 42% increase in the number of branching points at P7
• mice show defective vascular migration into the inner retina at P17
• mice develop vascular growth in the superficial plexus with glomeruloid vascular structures at P17
• lithium treatment from P1 to P16 reduces the retinal area of glomeruloid vessels by about 60%
• lithium treatment from P1 to P16 normalizes the appearance of finely pruned vessels and the abnormally increased vascular density in the superficial vascular layer
• mice show a complete absence of intralaminar (intermediate and deep layers of) retinal vessels at P17
• mice show fewer branching points in the central superficial vascular plexus of the retina at P7


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/09/2019
MGI 6.13
The Jackson Laboratory