Mouse Genome Informatics
cn
    Lrp1tm2Her/Lrp1tm2Her
Tg(Camk2a-cre)T29-1Stl/0

involves: 129S7/SvEvBrd * BALB/c * C57BL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• in the cortex of the brain at 12 months of age
• decrease in spine densities of apical oblique and basal shaft dendrites of pyramidal neurons in the cortex and in the CA1 region of the hippocampus at 18 months but not at 12 months of age
• expression analysis indicates an age dependent decrease in synaptic density
• significant increase in apoptotic cells in the cortex and hippocampus at 24 months but not at 18 months of age
• significantly lower levels of sulfatide, galactosylceramide, cholesterol and triglyceride in the cortex of the brain at 12 months of age
• amyloid-beta levels are decreased in the hippocampus at 18 months of age, indicating that the neurodegeneration likely occurs by an amyloid-beta independent mechanism
• increase in reactive astrocytes and microglial activation in the CA1 region of the hippocampus and in the dentate gyrus but not in the CA3 region of the hippocampus at 18 months of age
• severely reduced in hippocampal slices at 18 months of age

behavior/neurological
• exhibit significantly less freezing time than controls at 18 months of age
• exhibit significantly less freezing time than controls at 18 months of age
• develops by 13 months of age
• at 18 months of age
• in an open field test at 18 months of age

homeostasis/metabolism
• significantly lower levels of sulfatide and galactosylceramide in the cortex of the brain at 12 months of age
• in the cortex of the brain at 12 months of age
• in the cortex of the brain at 12 months of age

immune system
• increase in reactive astrocytes and microglial activation in the CA1 region of the hippocampus and in the dentate gyrus but not in the CA3 region of the hippocampus at 18 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:167724