About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4943741
Allelic
Composition
Lrp1tm2Her/Lrp1tm2Her
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: 129S7/SvEvBrd * BALB/c * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (94 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in the cortex of the brain at 12 months of age
• decrease in spine densities of apical oblique and basal shaft dendrites of pyramidal neurons in the cortex and in the CA1 region of the hippocampus at 18 months but not at 12 months of age
• expression analysis indicates an age dependent decrease in synaptic density
• significant increase in apoptotic cells in the cortex and hippocampus at 24 months but not at 18 months of age
• significantly lower levels of sulfatide, galactosylceramide, cholesterol and triglyceride in the cortex of the brain at 12 months of age
• amyloid-beta levels are decreased in the hippocampus at 18 months of age, indicating that the neurodegeneration likely occurs by an amyloid-beta independent mechanism
• increase in reactive astrocytes and microglial activation in the CA1 region of the hippocampus and in the dentate gyrus but not in the CA3 region of the hippocampus at 18 months of age
• severely reduced in hippocampal slices at 18 months of age

behavior/neurological
• exhibit significantly less freezing time than controls at 18 months of age
• exhibit significantly less freezing time than controls at 18 months of age
• develops by 13 months of age
• at 18 months of age
• in an open field test at 18 months of age

homeostasis/metabolism
• significantly lower levels of sulfatide and galactosylceramide in the cortex of the brain at 12 months of age
• in the cortex of the brain at 12 months of age
• in the cortex of the brain at 12 months of age

immune system
• increase in reactive astrocytes and microglial activation in the CA1 region of the hippocampus and in the dentate gyrus but not in the CA3 region of the hippocampus at 18 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:167724


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory