Phenotypes Associated with This Genotype

Genotype
MGI:4943740

• Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her; Tg(Tagln-cre)1Her/0
• Genetic Background: B6.Cg-Lrp1^tm2Her Tg(Tagln-cre)1Her

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta tunica media morphology ( J:167799 )

• medial thickness is doubled with an increase in the number of cell nuclei

abnormal aorta elastic tissue morphology ( J:167799 )

• increase in the number of disruptions of the elastic layers

abnormal aorta smooth muscle morphology ( J:167799 )

• freshly isolated cells are more epithelioid shaped compared to the spindled shaped cells from control mice

• alpha-actin filaments are less abundant and often disrupted in quiescent smooth muscle cells

abnormal vascular smooth muscle physiology ( J:167799 )

• aortic smooth muscle cells challenged with PDGF-bb display more rapid alpha-actin filament disassembly and fillapodial extension and enhanced proliferation and migration compared to controls

• cultured aortic smooth muscle cells show enhanced serum induced cell growth

decreased vasoconstriction ( J:167799 )

• aortic rings mice fail to reach the 50% level of force generation at any concentration of KCl and phenylephrine tested

abnormal vascular wound healing ( J:167799 )

• increase in neointimal formation and prolonged neointimal hyperplasia following endothelial denudation of carotid arteries

homeostasis/metabolism

abnormal vascular wound healing ( J:167799 )

• increase in neointimal formation and prolonged neointimal hyperplasia following endothelial denudation of carotid arteries

muscle

abnormal aorta smooth muscle morphology ( J:167799 )

• freshly isolated cells are more epithelioid shaped compared to the spindled shaped cells from control mice

• alpha-actin filaments are less abundant and often disrupted in quiescent smooth muscle cells

abnormal vascular smooth muscle physiology ( J:167799 )

• aortic smooth muscle cells challenged with PDGF-bb display more rapid alpha-actin filament disassembly and fillapodial extension and enhanced proliferation and migration compared to controls

• cultured aortic smooth muscle cells show enhanced serum induced cell growth

decreased vasoconstriction ( J:167799 )

• aortic rings mice fail to reach the 50% level of force generation at any concentration of KCl and phenylephrine tested