Phenotypes Associated with This Genotype

Genotype
MGI:4943490

• Allelic Composition: Cd44^tm1Mak/Cd44⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:99032 )

• trend towards decreased N-formyl methionyl leucyl phenylalanine (fMLP)-directed polarization in the pool of freshly isolated neutrophils compared with wild-type cells

• trend towards slower migration speed

• reduced numbers of neutrophil infiltrating the peritoneal cavity in response to thioglycollate in vivo

• trend towards reduced numbers of neutrophil in response to fMLP in vivo

cellular

abnormal leukocyte migration ( J:99032 )

• trend towards decreased N-formyl methionyl leucyl phenylalanine (fMLP)-directed polarization in the pool of freshly isolated neutrophils compared with wild-type cells

• trend towards slower migration speed

• reduced numbers of neutrophil infiltrating the peritoneal cavity in response to thioglycollate in vivo

• trend towards reduced numbers of neutrophil in response to fMLP in vivo

hematopoietic system

abnormal leukocyte migration ( J:99032 )

• trend towards decreased N-formyl methionyl leucyl phenylalanine (fMLP)-directed polarization in the pool of freshly isolated neutrophils compared with wild-type cells

• trend towards slower migration speed

• reduced numbers of neutrophil infiltrating the peritoneal cavity in response to thioglycollate in vivo

• trend towards reduced numbers of neutrophil in response to fMLP in vivo