Phenotypes Associated with This Genotype

Genotype
MGI:4943460

• Allelic Composition: Cd44^tm1Mak/Cd44^tm1Mak
• Genetic Background: D1.129P2-Cd44^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to induced arthritis ( J:95275 )

• more susceptible to collagen-induced arthritis (CIA) than wild-type mice

• develope arthritis 25 ([?]1) days after injection of a single dose (200 ug) of collagen

• more extensive chondrolysis

• enhanced accumulation of hyaluronan

skeleton

increased susceptibility to induced arthritis ( J:95275 )

• more susceptible to collagen-induced arthritis (CIA) than wild-type mice

• develope arthritis 25 ([?]1) days after injection of a single dose (200 ug) of collagen

• more extensive chondrolysis

• enhanced accumulation of hyaluronan