Phenotypes Associated with This Genotype

Genotype
MGI:4942402

• Allelic Composition: Cd44^tm1Mak/Cd44^tm1Mak; Itgal^tm1Mak/Itgal^tm1Mak
• Genetic Background: B6.129P2-Cd44^tm1Mak Itgal^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired natural killer cell mediated cytotoxicity ( J:110889 )

• further reduced IL-2-activated NK cytotoxicity against tumor cell lines than that of the single mutation mice

• further impaired binding (conjugate formation) to target cells than that of the single mutation mice

• normal lymphocyte development and normal numbers of leukocyte subpopulations

• normal IL-2-activated NK cell differentiation and activation

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:110889 )

• further reduced IL-2-activated NK cytotoxicity against tumor cell lines than that of the single mutation mice

• further impaired binding (conjugate formation) to target cells than that of the single mutation mice

• normal lymphocyte development and normal numbers of leukocyte subpopulations

• normal IL-2-activated NK cell differentiation and activation