Mouse Genome Informatics
hm
    Ift80Gt(AN0245)Wtsi/Ift80Gt(AN0245)Wtsi
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• fewer than expected mice are present at P0
• fewer than expected mice are present at P0

skeleton
• flattened in the anterior posterior axis
• the hypertrophic chondrocyte zone is poorly organized and smaller than in wild-type mice
• shortening is slightly more severe in distal rather than proximal limb elements
• ribs exhibit an irregular margin between bone and cartilage compared with wild-type mice
• thoracic cages are constricted compared to in wild-type mice

limbs/digits/tail
• bilateral in hind limbs with a single extra digit longer than other digits

growth/size/body
N
• mice exhibit normal sidedness, indicating normal ciliary function (J:169236)

renal/urinary system
N
• at P21, mice exhibit normal kidney morphology (J:169236)

vision/eye
N
• at P21, mice exhibit normal retina layers (J:169236)

craniofacial
• flattened in the anterior posterior axis

Mouse Models of Human Disease
OMIM IDRef(s)
Short-Rib Thoracic Dysplasia 2 with or without Polydactyly; SRTD2 611263 J:169236
Short-Rib Thoracic Dysplasia 3 with or without Polydactyly; SRTD3 613091 J:169236