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Phenotypes Associated with This Genotype
Genotype
MGI:4942182
Allelic
Composition
Twist2tm1(cre)Dor/Twist2tm1(cre)Dor
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mice lack epidermal appendages unlike wild-type mice
• eyelashes are sparse or absent (lower lashes are absent) unlike in wild-type mice
• between the ears and eyes
• lower lashes are absent
• mice exhibit hypoplastic dermis unlike wild-type mice
• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice
• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice
• mice exhibit bitemporal lesions unlike wild-type mice

vision/eye
• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice
• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice
• lower lashes are absent

craniofacial
• ears are dysmorphic and low-set unlike wild-type mice

endocrine/exocrine glands
• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice
• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice

hearing/vestibular/ear
• ears are dysmorphic and low-set unlike wild-type mice

adipose tissue

growth/size/body
• mice exhibit short anterior-posterior head diameters compared with wild-type mice
• ears are dysmorphic and low-set unlike wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Focal Facial Dermal Dysplasia 3, Setleis Type; FFDD3 227260 J:169191


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory