Phenotypes Associated with This Genotype

Genotype
MGI:4942182

• Allelic Composition: Twist2^tm1(cre)Dor/Twist2^tm1(cre)Dor
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal skin adnexa morphology ( J:169191 )

• mice lack epidermal appendages unlike wild-type mice

decreased subcutaneous adipose tissue amount ( J:169191 )

abnormal hair growth ( J:169191 )

• eyelashes are sparse or absent (lower lashes are absent) unlike in wild-type mice

alopecia ( J:169191 )

• between the ears and eyes

loss of eyelid cilia ( J:169191 )

• lower lashes are absent

sparse hair ( J:169191 )

abnormal dermal layer morphology ( J:169191 )

• mice exhibit hypoplastic dermis unlike wild-type mice

absent Meibomian glands ( J:169191 )

• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice

Meibomian gland hypoplasia ( J:169191 )

• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice

skin lesions ( J:169191 )

• mice exhibit bitemporal lesions unlike wild-type mice

thin skin ( J:169191 )

vision/eye

abnormal eye morphology ( J:169191 )

absent Meibomian glands ( J:169191 )

• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice

Meibomian gland hypoplasia ( J:169191 )

• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice

loss of eyelid cilia ( J:169191 )

• lower lashes are absent

craniofacial

abnormal craniofacial morphology ( J:169191 )

narrow snout ( J:169191 )

• snout is narrow

lowered ear position ( J:169191 )

• ears are dysmorphic and low-set unlike wild-type mice

endocrine/exocrine glands

absent Meibomian glands ( J:169191 )

• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice

Meibomian gland hypoplasia ( J:169191 )

• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice

hearing/vestibular/ear

lowered ear position ( J:169191 )

• ears are dysmorphic and low-set unlike wild-type mice

adipose tissue

decreased subcutaneous adipose tissue amount ( J:169191 )

growth/size/body

abnormal head morphology ( J:169191 )

• mice exhibit short anterior-posterior head diameters compared with wild-type mice

narrow snout ( J:169191 )

• snout is narrow

lowered ear position ( J:169191 )

• ears are dysmorphic and low-set unlike wild-type mice