Mouse Genome Informatics
hm
    Twist2tm1(cre)Dor/Twist2tm1(cre)Dor
involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
integument
• mice lack epidermal appendages unlike wild-type mice
• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice
• in some mice
• eyelashes are sparse or absent (lower lashes are absent) unlike in wild-type mice
• between the ears and eyes
• lower lashes are absent
• mice exhibit hypoplastic dermis unlike wild-type mice
• mice exhibit bitemporal lesions unlike wild-type mice

vision/eye
• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice
• in some mice
• lower lashes are absent

craniofacial
• ears are dysmorphic and low-set unlike wild-type mice

endocrine/exocrine glands
• mice exhibit absent or hypoplastic Meibomian glands unlike wild-type mice
• in some mice

hearing/vestibular/ear
• ears are dysmorphic and low-set unlike wild-type mice

adipose tissue

growth/size
• mice exhibit short anterior-posterior head diameters compared with wild-type mice
• ears are dysmorphic and low-set unlike wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Focal Facial Dermal Dysplasia 3, Setleis Type; FFDD3 227260 J:169191