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Phenotypes Associated with This Genotype
Genotype
MGI:4941931
Allelic
Composition		 Prickle2tm1Nue/Prickle2tm1Nue
Genetic
Background		 B6.Cg-Prickle2tm1Nue
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prickle2tm1Nue mutation (1 available); any Prickle2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:169136 )
• pentylenetetrazole-treated mice exhibit increased epileptiform discharges compared with similarly treated wild-type mice
abnormal seizure response to electrical stimulation ( J:169136 )
• mice exhibit decreased seizure threshold in a maximal electroconvulsive seizure threshold test compared with wild-type mice
• seizure rates are higher than in heterozygotes

nervous system
increased susceptibility to pharmacologically induced seizures ( J:169136 )
• pentylenetetrazole-treated mice exhibit increased epileptiform discharges compared with similarly treated wild-type mice
abnormal seizure response to electrical stimulation ( J:169136 )
• mice exhibit decreased seizure threshold in a maximal electroconvulsive seizure threshold test compared with wild-type mice
• seizure rates are higher than in heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory