Phenotypes Associated with This Genotype

Genotype
MGI:4941875

• Allelic Composition: Sla^tm1Weis/Sla^tm1Weis; Sla2^tm1Amch/Sla2^tm1Amch
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal dendritic cell differentiation ( J:169170 )

• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells

• however, LPS treatment partially rescues maturation

abnormal dendritic cell physiology ( J:169170 )

• bone marrow-derived dendritic cells treated with LPS and incubated with CD3-enriched cells elicit less T cell proliferation compared with similarly treated wild-type cells

• bone marrow-derived dendritic cells treated with LPS and pulsed with ovalbumin fail to induce increased production of IFN-gamma from Tg(DO11.10)10Dlo T cells compared with similarly treated wild-type cells

decreased interleukin-12 secretion ( J:169170 )

• in bone marrow-derived dendritic cells grown in LPS, GM-CSF alone, or GM-CSF with IL4

decreased tumor necrosis factor secretion ( J:169170 )

• in LPS-treated bone marrow-derived dendritic cells

hematopoietic system

hematopoietic system phenotype ( J:169170 )

N • mice exhibit normal hematological parameters

abnormal dendritic cell differentiation ( J:169170 )

• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells

• however, LPS treatment partially rescues maturation

cellular

abnormal dendritic cell differentiation ( J:169170 )

• bone marrow derived dendritic cell maturation induced by IL4 is impaired compared with wild-type cells

• however, LPS treatment partially rescues maturation