Phenotypes Associated with This Genotype

Genotype
MGI:4941850

• Allelic Composition: Gnao1^tm4Lbi/Gnao1^tm4Lbi; Tg(Pdx1-cre)89.1Dam/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreas morphology ( J:169627 )

• at P28 and P56, pancreatic insulin content is reduced compared to in wild-type mice

• however, insulin content at P1 is normal

decreased pancreatic beta cell mass ( J:169627 )

• at P56

abnormal pancreatic beta cell physiology ( J:169627 )

• unstimulated and glucose-stimulated beta cells increased docking and release of secretory vesicles compared with wild-type cells

• however, the total number of vesicles is normal

increased insulin secretion ( J:169627 )

• in stimulated pancreatic islet cells

homeostasis/metabolism

increased insulin secretion ( J:169627 )

• in stimulated pancreatic islet cells

increased circulating insulin level ( J:169627 )

• after glucose challenge

abnormal glucose tolerance ( J:169627 )

• in an intraperitoneal glucose tolerance test, mice exhibit improved glucose clearance compared with wild-type mice

• pertussis toxin-treated mice fail to exhibit an increase in glucose tolerance unlike similarly treated wild-type mice

• however, insulin sensitivity is normal