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Phenotypes Associated with This Genotype
Genotype
MGI:4941744
Allelic
Composition		 Pdpk1tm1Maka/Pdpk1tm1Maka
Tsc1tm1Djk/Tsc1tm1Djk
Tg(Gdf9-icre)5092Coo/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpk1tm1Maka mutation (0 available); any Pdpk1 mutation (141 available)
Tg(Gdf9-icre)5092Coo mutation (1 available)
Tsc1tm1Djk mutation (2 available); any Tsc1 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:155357 )
• although some primordial follicles are activated by P23, not all of them are activated as seen in single conditional homozygous Tsc1 mutants, indicating partial reversal of the overactivation of primordial follicles

reproductive system
abnormal ovarian follicle morphology ( J:155357 )
• although some primordial follicles are activated by P23, not all of them are activated as seen in single conditional homozygous Tsc1 mutants, indicating partial reversal of the overactivation of primordial follicles

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory