Phenotypes Associated with This Genotype

Genotype
MGI:4941735

• Allelic Composition: Tsc1^tm1Djk/Tsc1^tm1Djk; Tg(Gdf9-icre)5092Coo/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:155357 )

♀ • mutants exhibit premature activation of the entire primordial follicle pool by P23, leading to follicle depletion and premature ovarian failure in early adulthood (2-3 months of age)

♀ • injection with rapamycin reverses the overactivation of primordial follicles, indicative that mTORC1 activity is responsible for increased activation of follicles

premature ovarian failure ( J:155357 )

♀ • premature ovarian failure in early adulthood (2-3 months of age)

mortality/aging

premature ovarian failure ( J:155357 )

♀ • premature ovarian failure in early adulthood (2-3 months of age)

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:155357 )

• higher levels at 3-4 months of age

increased circulating luteinizing hormone level ( J:155357 )

• higher levels at 3-4 months of age

reproductive system

abnormal ovarian follicle morphology ( J:155357 )

♀ • mutants exhibit premature activation of the entire primordial follicle pool by P23, leading to follicle depletion and premature ovarian failure in early adulthood (2-3 months of age)

♀ • injection with rapamycin reverses the overactivation of primordial follicles, indicative that mTORC1 activity is responsible for increased activation of follicles

premature ovarian failure ( J:155357 )

♀ • premature ovarian failure in early adulthood (2-3 months of age)

reduced female fertility ( J:155357 )

♀ • from 6-27 weeks of age, females produce at most 2 litters of normal size and then become infertile after around 12-13 weeks