Phenotypes Associated with This Genotype

Genotype
MGI:4941631

• Allelic Composition: Hoxa5^tm1Rob/Hoxa5^tm1Rob; Pdgfra^{tm11(EGFP)Sor}/Pdgfra⁺
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal pulmonary alveolar parenchyma morphology ( J:113378 )

• at E16.5, most alveolar myofibroblast progenitors fail to spread distally and remain clustered around the epithelium, unlike in wild-type lungs where progenitors are dispersed in the lung parenchyma

• alveolar myofibroblast progenitors also fail to invade some regions of the developing lung

cellular

abnormal cell migration ( J:113378 )

• wounding assays performed on primary mesenchymal cells isolated from E15.5 lungs revealed that, unlike wild-type cells which invade the wounded area within 12 hrs and fill the gap by 24 hrs, mutant cells display reduced migration at both time points

• however, no difference in migratory behavior is observed in response to gelatin in Boyden chambers