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Phenotypes Associated with This Genotype
Genotype
MGI:4941217
Allelic
Composition		 Bmp4tm1Jfm/Bmp4tm1Jfm
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Tg(Mef2c-cre)2Blk/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (21 available)
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (7 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiac outflow tract development ( J:169047 )
• proximal outflow tract mesenchyme deficiency is more severe than in mutant mice wild-type for Mir17-92
• failure of fusion between proximal mesenchyme and outflow tract septum
abnormal truncus arteriosus septation ( J:169047 )
• at E14.5 and E18.5, a deficiency in the separation of the proximal outflow tract is seen
• deficiency is more severe than in mutant mice wild-type for Mir17-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory