Phenotypes Associated with This Genotype

Genotype
MGI:4941216

• Allelic Composition: Mirc1^tm1.2Tyj/Mirc1^tm1.2Tyj
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

double outlet right ventricle ( J:169047 )

ventricular septal defect ( J:169047 , J:223213 )

• ventricular septal defect observed in E18.5 embryos (J:223213)

decreased heart right ventricle size ( J:169047 )

mortality/aging

perinatal lethality, complete penetrance ( J:223213 )

limbs/digits/tail

fused carpal bones ( J:188762 )

• E18.5 mutants exhibit fusion of the proximal carpal bones

abnormal phalanx morphology ( J:188762 )

• complete absence of the mesophalanx of the fifth digit is seen in E18.5 mutants

brachyphalangia ( J:188762 )

• E18.5 mutants exhibit the presence of a small mesophalanx of the second digit and hypoplasia of the first digital ray

abnormal forelimb zeugopod morphology ( J:188762 )

• E18.5 mutants exhibit dysmorphic zeugopods

abnormal hindlimb zeugopod morphology ( J:188762 )

• E18.5 mutants exhibit dysmorphic zeugopods

respiratory system

pulmonary hypoplasia ( J:223213 )

skeleton

fused carpal bones ( J:188762 )

• E18.5 mutants exhibit fusion of the proximal carpal bones

abnormal phalanx morphology ( J:188762 )

• complete absence of the mesophalanx of the fifth digit is seen in E18.5 mutants

brachyphalangia ( J:188762 )

• E18.5 mutants exhibit the presence of a small mesophalanx of the second digit and hypoplasia of the first digital ray

cervical vertebral fusion ( J:188762 )

• all E18.5 mutants exhibit fusion of the cervical vertebrae

delayed endochondral bone ossification ( J:188762 )

• E18.5 mutants exhibit a severe and general delay of endochondral ossification

delayed intramembranous bone ossification ( J:188762 )

• E18.5 mutants exhibit a severe and general delay of membranous ossification, with delayed ossification of occipital, parietal and frontal bones

growth/size/body

microcephaly ( J:188762 )

• seen in all E18.5 mutants