Phenotypes for Bmp2 Bmp4 Tg(Mef2c-cre)2Blk MGI:4941214 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Bmp2^tm1Jfm/Bmp2^tm1Jfm Bmp4^tm1Jfm/Bmp4^tm1Jfm Tg(Mef2c-cre)2Blk/0
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2^tm1Jfm mutation (1 available); any Bmp2 mutation (25 available)
Bmp4^tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Tg(Mef2c-cre)2Blk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:169047 )

• no embryos are found after E12.5

cardiovascular system

abnormal heart ventricle outflow tract morphology ( J:169047 )

• dramatic reduction in the amount of sarcomeric myosin

pericardial edema ( J:169047 )

homeostasis/metabolism

pericardial edema ( J:169047 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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