Phenotypes Associated with This Genotype

Genotype
MGI:4941161

• Allelic Composition: \Gt(ROSA)26Sor^{tm3(myc*S62A)Rcse}/\Gt(ROSA)26Sor^{tm3(myc*S62A)Rcse}; \Tg(Wap-cre)11738Mam/0
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

aneuploidy ( J:169403 )

• in mammary epithelial cells

polyploidy ( J:169403 )

• in mammary epithelial cells

chromosomal instability ( J:169403 )

• mammary epithelial cells exhibit increased chromosomal instability with high rates of polyploidy and aneuploidy compared with control cells

neoplasm

increased brain tumor incidence ( J:169403 )

• all mice succumb to brain tumors with a latency of 54 weeks

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:169403 )

♀ • mammary ductal branching is decreased compared to in control mice

abnormal mammary gland alveolus morphology ( J:169403 )

♀ • parous mice exhibit a reduced number of alveoli compared with Gt(ROSA)26Sor^tm1(myc)Rcse/Gt(ROSA)26Sor^tm1(myc)Rcse Tg(Wap-cre)11738Mam mice

integument

abnormal branching of the mammary ductal tree ( J:169403 )

♀ • mammary ductal branching is decreased compared to in control mice

abnormal mammary gland alveolus morphology ( J:169403 )

♀ • parous mice exhibit a reduced number of alveoli compared with Gt(ROSA)26Sor^tm1(myc)Rcse/Gt(ROSA)26Sor^tm1(myc)Rcse Tg(Wap-cre)11738Mam mice

nervous system

increased brain tumor incidence ( J:169403 )

• all mice succumb to brain tumors with a latency of 54 weeks