Phenotypes Associated with This Genotype

Genotype
MGI:4941159

• Allelic Composition: Gt(ROSA)26Sor^tm1(Myc)Rcse/Gt(ROSA)26Sor^tm1(Myc)Rcse; Tg(Wap-cre)11738Mam/0
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal chromosome number ( J:169403 )

• 5 of 20 mammary epithelial cells exhibit abnormal karyotype compared with 2 of 20 control cells

chromosomal instability ( J:169403 )

• 5 of 20 mammary epithelial cells exhibit abnormal karyotype compared with 2 of 20 control cells

neoplasm

neoplasm ( J:169403 )

N • mice do not develop tumors

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:169403 )

♀ • mammary ductal branching is increased compared to in control mice

abnormal mammary gland epithelium physiology ( J:169403 )

♀ • apoptosis of mammary gland epithelium during involution is increased compared to in control mice

increased mammary gland apoptosis ( J:169403 )

♀ • apoptosis of mammary gland epithelium during involution is increased compared to in control mice

integument

abnormal branching of the mammary ductal tree ( J:169403 )

♀ • mammary ductal branching is increased compared to in control mice

abnormal mammary gland epithelium physiology ( J:169403 )

♀ • apoptosis of mammary gland epithelium during involution is increased compared to in control mice

increased mammary gland apoptosis ( J:169403 )

♀ • apoptosis of mammary gland epithelium during involution is increased compared to in control mice